Original Manuscripts
2024
Theodoraki MN, Huber D, Hofmann L, Werner L, Idel C, Fleckner J, Plötze-Martin K, Schütt L, Brunner C, Depping R, Hoffmann TK, Bruchhage KL, Pries R
Type 2-like polarization and elevated CXCL4 secretion of monocyte derived macrophages upon internalization of plasma-derived exosomes from head and neck cancer patients
BMC Cancer. 2024 Sep 20;24(1):1173. doi: 10.1186/s12885-024-12948-6
Rother F, Depping R, Popova E, Huegel S, Heiler A, Hartmann E, Bader M
Karyopherin α2 is a maternal effect gene required for early embryonic development and female fertility in mice
FASEB J. 2024 Apr 30;38(8):e23623. doi: 10.1096/fj.202301572RR
Ralph Pries, Friederike Katharina Kosyna, Reinhard Depping, Kirstin Plötze-Martin, Christian Lange, Svenja Meyhöfer, Sebastian M. Meyhöfer, Jens U. Marquardt, Karl-Ludwig Bruchhage & Armin Steffen
Distinguishing the impact of distinct obstructive sleep apnea syndrome (OSAS) and obesity related factors on human monocyte subsets
Scientific Reports volume 14, Article number: 340 (2024)
2023
Hoffmeister H, Holzinger S, Dürr MS, Bruckmann A, Schindler S, Gröbner-Ferreira R, Depping R, Längst G
Characterization of the nuclear import of human CHD4-NuRD complex
J Cell Sci. 2023 Mar 2:jcs.260724. doi: 10.1242/jcs.260724. Online ahead of print. PMID: 36861403
2022
Günter CI, Ilg FP, Hapfelmeier A, Egert-Schwender S, Jelkmann W, Giri S, Bader A, Machens HG; and EPO in Burns Study Group
Relation Between Gender and Concomitant Medications With Erythropoietin-Treatment on Wound Healing in Burn Patients. Post Hoc Subgroup-Analysis of the Randomized, Placebo-Controlled Clinical Trial "EPO in Burns
Front Pharmacol. 13: 812888, 2022. doi: 10.3389/fphar.2022.812888. eCollection 2022. PMID: 35847006
Achner L, Klersy T, Fels B, Reinberger T, Schmidt CX, Groß N, Hille S, Müller OJ, Aherrahrou Z, Kusche-Vihrog K, Raasch W
AFM-based nanoindentation indicates an impaired cortical stiffness in the AAV-PCSK9 DY atherosclerosis mouse model
Pflugers Arch 2022 doi: 10.1007/s00424-022-02710-x.
Pacia MZ, Chorazy N, Sternak M, Fels B, Pacia M, Kepczynski M, Kusche-Vihrog K, Chlopicki S
Rac1 regulates lipid droplets formation, nanomechanical, and nanostructural changes induced by TNF in vascular endothelium in the isolated murine aorta
Cell Mol Life Sci. 2022 doi: 10.1007/s00018-022-04362-7
Matyjaszczyk-Gwarda K, Kij A, Olkowicz M, Fels B, Kusche-Vihrog K, Walczak M, Chlopicki S
Simultaneous quantification of selected glycosaminoglycans by butanolysis-based derivatization and LC-SRM/MS analysis for assessing glycocalyx disruption in vitro and in vivo
Talanta. 2022 Feb 1;238(Pt 1):123008. doi: 10.1016/j.talanta.2021.123008. Epub 2021 Oct 28.PMID: 34857342
Graßhoff H, Müller-Fielitz H, Dogbevia GK, Körbelin J, Bannach J, Vahldieck CM, Kusche-Vihrog K, Jöhren O, Müller OJ, Nogueiras R, Prevot V, Schwaninger M
Short regulatory DNA sequences to target brain endothelial cells for gene therapy
J Cereb Blood Flow Metab. 2022 doi: 10.1177/0271678X211039617
Fels B, Acharya S, Vahldieck C, Graf T, Käding N, Rupp J, Kusche-Vihrog K
Mineralocorticoid receptor-antagonism prevents COVID-19-dependent glycocalyx damage
Pflugers Arch. 2022, doi: 10.1007/s00424-022-02726-3
Cosgun Z C, Sternak M, Fels, B, Bar A, Kwiatkowski G, Pacia M Z, Herrnböck L, Lindemann M, Stegbauer J, Höges S, Chlopicki S, Kusche-Vihrog K
Rapid shear stress-dependent ENaC membrane insertion is mediated by the endothelial glycocalyx and the mineralocorticoid receptor
Cell Mol Life Sci, 2022 Apr 10;79(5):235 doi: 10.1007/s00018-022-04260-y
2021
Meusel M, Wegerich P, Bode B, Stawschenko E, Kusche-Vihrog K, Hellbrück H, Gehring H
Measurement of Blood Pressure by Ultrasound-The Applicability of Devices, Algorithms and a View in Local Hemodynamics
Diagnostics (Basel). 2021 doi: 10.3390/diagnostics11122255
Ozkurt M, Hellwig-Bürgel T, Depping R, Kadabere S, Ozyurt R, Karadag A, Erkasap N
miR663 Prevents Epo Inhibition Caused by TNF-Alpha in Normoxia and Hypoxia
Int J Endocrinol 2021 Jul 27; 2021:3670499. doi: 10.1155/2021/3670499.eCollection
Roy-Chowdhury E, Brauns N, Helmke A, Nordlohne J, Bräsen JH, Schmitz J, Volkmann J, Fleig SV, Kusche-Vihrog K, Haller H, von Vietinghoff S
Human CD16+ monocytes promote a pro-atherosclerotic endothelial cell phenotype via CX3CR1-CX3CL1 interaction
Cardiovasc Res. 2021 doi: 10.1093/cvr/cvaa234
von Fallois M, Kosyna FK, Mandl M, Landesman Y, Dunst J, Depping R
Selinexor decreases HIF-1α via inhibition of CRM1 in human osteosarcoma and hepatoma cells associated with an increased radiosensitivity
J Cancer Res Clin Oncol 2021 Apr 15 doi: 10.1007/s00432-021-03626-2. Online ahead of print.
2020
Hesse B, Rovas A, Buscher K, Kusche-Vihrog K, Brand M, Di Marco GS, Kielstein JT, Pavenstädt H, Linke WA, Nofer JR, Kümpers P, Lukasz A
Symmetric dimethylarginine in dysfunctional high-density lipoprotein mediates endothelial glycocalyx breakdown in chronic kidney disease
Kidney Int. 2020 doi: 10.1016/j.kint.2019.10.017
Kuntze A, Goetsch O, Fels B, Najder K, Unger A, Wilhelmi M, Sargin S, Schimmelpfennig S, Neumann I, Schwab A, Pethő Z
Protonation of Piezo1 Impairs Cell-Matrix Interactions of Pancreatic Stellate Cells
Front Physiol. 2020 doi: 10.3389/fphys.2020.00089
Post H, Hundt JE, Zhang G, Depping R, Rose C, Langan EA, Paus R
Thyroxine Restores Severely Impaired Cutaneous Re-Epithelialisation and Angiogenesis in a Novel Preclinical Assay for Studying Human Skin Wound Healing Under "Pathological" Conditions Ex Vivo
Arch Dermatol Res 2020 Jun 22. doi: 10.1007/s00403-020-02092-z. Online ahead of print
2019
Depping R, von Fallois M, Landesman Y, Kosyna FK
The Nuclear Export Inhibitor Selinexor Inhibits Hypoxia Signaling Pathways And 3D Spheroid Growth Of Cancer Cells.
Onco Targets Ther. 2019 Oct 11;12:8387-8399. doi: 10.2147/OTT.S213208. eCollection 2019
Depping R, Seeger K
H-NMR spectroscopy shows cellular uptake of HEPES buffer by human cell lines-an effect to be considered in cell culture experiments
Anal Bioanal Chem. 2019 Feb;411(4):797-802
Fels J, Kusche-Vihrog K.
Endothelial Nanomechanics in the Context of Endothelial (Dys)function and Inflammation.
Antioxid Redox Signal. 2019 Mar 1;30(7):945-959. doi: 10.1089/ars.2017.7327.
Streichert K, Seitz C, Hoffmann E, Boos I, Jelkmann W, Brunner T, Unverzagt C, Rubini M
Synthesis of erythropoietins site-specifically cunjugated with complex-type N-glycans
Chembiochem doi: 10.1002/cbic.201900023, 2019
2018
Bartolomaeus H, Balogh A, Yakoub M, Homann S, Markó L, Höges S, Tsvetkov D, Krannich A, Wundersitz S, Avery EG, Haase N, Kräker K, Hering L, Maase M, Kusche-Vihrog K, Grandoch M, Fielitz J, Kempa S, Gollasch M, Zhumadilov Z, Kozhakhmetov S, Kushugulova A, Eckardt KU, Dechend R, Rump LC, Forslund SK, Müller DN, Stegbauer J, Wilck N.
The Short-Chain Fatty Acid Propionate Protects from Hypertensive Cardiovascular Damage.
Circulation. 2018 Dec 4. doi: 10.1161/CIRCULATIONAHA.118.036652.
Günter CI, Machens HG, Ilg FP, Hapfelmeier A, Jelkmann W, Egert-Schwender S, Giri S, “EPO in Burns” Study Group, Bader A.
A Randomized Controlled Trial: Regenerative Effects, Efficacy and Safety of Erythropoietin in Burn and Scalding Injuries
Front Pharmacol 2018 Oct 31;9:951. doi: 10.3389/fphar.2018.00951. eCollection 2018
Maase M, Rygula A, Pacia MZ, Proniewski B, Mateuszuk L, Sternak M, Kaczor A, Chlopicki S, Kusche-Vihrog K.
Combined Raman- and AFM-based detection of biochemical and nanomechanical features of endothelial dysfunction in aorta isolated from ApoE/LDLR-/- mice.
Nanomedicine. 2018 Dec 11;16:97-105. doi: 10.1016/j.nano.2018.11.014.
Ménard M, Costechareyre C, Ichim G, Blachier J, Neves D, Jarrosson-Wuilleme L, Depping R, Koster J, Saintigny P, Mehlen P, Tauszig-Delamasure S
Hey1- and p53-dependent TrkC proapoptotic activity controls neuroblastoma growth
PLoS Biol. 2018 May 11;16(5):e2002912. doi: 10.1371/journal.pbio.2002912. [Epub ahead of print]
Sowa AS, Martin E, Martins IM, Schmidt J, Depping R, Weber JJ, Rother F, Hartmann E, Bader M, Riess O, Tricoire H, Schmidt T
Karyopherin α-3 is a key protein in the pathogenesis of spinocerebellar ataxia type 3 controlling the nuclear localization of ataxin-3
Proc Natl Acad Sci U S A: 115(11):E2624-E2633, Epub 2018
Tazat K, Schindler S, Depping R, Mabjeesh NJ
Septin 9 isoform 1 (SEPT9_i1) specifically interacts with importin-α7 to drive hypoxia-inducible factor (HIF)-1α nuclear translocation.
Cytoskeleton (Hoboken). 2018 May 9. doi: 10.1002/cm.21450. [Epub ahead of print]
2017
Krämer BK, Hausberg M, Sanner B, Kusche-Vihrog K, Weil J, Weisser B, Wenzel U, Trenkwalder P
für die Task Force Wissenschaftliche Stellungnahmen und Leitlinien
der DHL®. [Blood Pressure Measurement and Treatment Targets: Position Paper of
the DHL® Task Force Scientific Statements and Guidelines].
Dtsch Med Wochenschr.
2017 Sep;142(19):1446-1447. doi: 10.1055/s-0043-117070.
Lukasz A, Hillgruber C, Oberleithner H, Kusche-Vihrog K, Pavenstädt H, Rovas A, Hesse B, Goerge T, Kümpers P.
Endothelial glycocalyx breakdown is mediated by angiopoietin-2.
Cardiovasc Res. 2017 May 1;113(6):671-680. doi:
10.1093/cvr/cvx023.
Mandl M, Depping R
ARNT is a potential direct HIF-1 target gene in human Hep3B hepatocellular carcinoma cells
Cancer Cell Int 17:77 doi: 10.1186/s 12935-017-0446-2, 2017
Mewes M, Nedele J, Schelleckes K, Bondareva O, Lenders M, Kusche-Vihrog K, Schnittler HJ, Brand SM, Schmitz B, Brand E.
Salt-induced Na(+)/K(+)-ATPase-?/? expression involves soluble adenylyl cyclase in endothelial cells.
Pflugers Arch. 2017 Oct;469(10):1401-1412. doi: 10.1007/s00424-017-1999-6.
Schierke F, Wyrwoll MJ, Wisdorf M, Niedzielski L, Maase M, Ruck T, Meuth SG, Kusche-Vihrog K.
Nanomechanics of the endothelial glycocalyx contribute to
Na(+)-induced vascular inflammation.
Sci Rep. 2017 Apr 13;7:46476. doi:
10.1038/srep46476.
Tarjus A, Maase M, Jeggle P, Martinez-Martinez E, Fassot C, Loufrani L, Henrion D, Hansen PBL, Kusche-Vihrog K, Jaisser F.
The endothelial ?ENaC contributes to vascular endothelial function in vivo.
PLoS One. 2017 Sep 26;12(9):e0185319. doi: 10.1371/journal.pone.0185319. eCollection 2017.
Windler C, Gey C, Seeger K
Skin melanocytes and fibroblasts show different changes in choline metabolism during cellular senescence
Mech Ageing Dev 164:82-90, 2017
Richter A, Hollstein R, Hebert E, Vulinovic F, Eckhold J, Osmanovic A, Depping R, Kaiser FJ, Lohmann K
In-depth Characterization of the Homodimerization Domain of the Transcription Factor THAP1 and Dystonia-Causing Mutations Therein
J Mol Neurosci 10.1007/s 12031-017-0904-2, 2017 [Epub ahead of print]
Wolff M, Kosyna FK, Dunst J, Jelkmann W, Depping R
Impact of hypoxia inducible factors on estrogen receptor expression in breast cancer cells
Arch Biochem Biophys 613:23-30, 2017
2016
Kauffenstein G, Tamareille S, Prunier F, Roy C, Ayer A, Toutain B, Billaud M, Isakson BE, Grimaud L, Loufrani L, Rousseau P, Abraham P, Procaccio V, Monyer H, de Wit C, Boeynaems JM, Robaye B, Kwak BR, Henrion D
Central Role of P2Y6 UDP Receptor in Arteriolar Myogenic Tone
Arterioscler Thromb Vasc 36(8): 1598-606, 2016
Segura-Puimedon M, Mergia E, Al-Hasani J, Aherrahrou R, Stoelting S, Kremer F, Freyer J, Koesling D, Erdmann J, Schunkert H, de Wit C, Aherrahrou Z
Proatherosclerotic Effect of the alpha1-Subunit of Soluble Guanylyl Cyclase ba Promoting Smooth Muscle Phenotypic Switching
Am J Pathol 186(8): 2220-31, 2016
Mandl M, Lieberum MK, Depping R
A HIF-1α-driven feed-forward loop augments HIF signalling in Hep3B cells by upregulation of ARNT
Cell Death Dis 7(6): e2284, 2016
Kramer J, Schwanbeck R, Pagel H, Cakiroglu F, Rohwedel J, Just U
Inhibition of Notch Signaling Ameliorates Acute Kidney Failure and Downregulates Platelet-Derived Growth Factor Receptor ß in the Mouse Model
Cells Tissues Organs 201(2): 109-17, 2016
Cakiroglu F, Enders-Comberg SM, Pagel H, Rohwedel J, Lehnert H, Kramer J
Erythropoietin-enhanced endothelial progenitor cell recruitment in peripheral blood and renal vessels during experimental acute kidney injury in rats
Cell Biol Int 40(3): 298-307, 2016
2015
Gemoll T, Epping F, Heinrich L, Fritzsche B, Roblick UJ, Szymczak S, Hartwig S, Depping R, Bruch, HP, Thorns C, Lehr S, Paech A, Habermann JK
Increased cathepsin D protein expression is a biomarker for osteosarcomas, pulmonary metastases and other bone malignancies
Oncotarget 6(18): 16517-26, 2015
Mandl M, Lieberum MK, Dunst J, Depping R
The expression level of the transcription factor Aryl hydrocarbon receptor nuclear translocator (ARNT) determines cellular survival after radiation treatment
Radiation Oncology 10:229, 2015
Kosyna FK, Nagel M, Kluxen L, Kraushaar K, Depping R
The importin α/β-specific inhibitor Ivermectin affects HIF-dependent hypoxia response pathways
Biol Chem pii: /j/bchm.ahead-of-print/hsz-2015-0171/hsz-2015-0171.xml [Epub ahead of print]
Kessler T, Zhang L, Liu Z, Yin X, Huang Y, Wang Y, Fu Y, Mayr M, Ge Q, Xu Q, Zhu Y, Wang X, Schmidt K, de Wit C, Erdmann J, Schunkert H, Aherrahrou Z, Kong W
ADAMTS-7 inhibits re-endothelialization of injured arteries and promotes vascular remodeling through cleavage of thrombospondin-1
Circulation 131(13):1191-201, 2015
Schmidt VJ, Hilgert JG, Covi JM, Leibig N, Wietbrock JO, Arkudas A, Polykandriotis E, de Wit C
Flow increase is decisive to initiate angiogenesis in veins exposed to altered hemodynamics
PLoS One 10(1):e0117407, 2015
Schraivogel D, Schindler SG, Danner J, Kremmer E, Pfaff J, Hannus S, Depping R, Meister G
Importin-beta facilitates nuclear import of human GW proteins and balances cytoplasmic gene silencing protein levels
Nucleic Acids Res. 2015 Jul 13. pii: gkv705. [Epub ahead of print]
Sun W, Kosyna FK, Jelkmann W, Depping R
Cell Physiol Biochem 37:2257-2264, 2015
2014
Erogullari A, Hollstein R, Seibler P, Braunholz D, Koschmidder E, Depping R, Eckhold J, Lohnau T, Gillessen-Kaesbach G, Grünewald A, Rakovic A, Lohmann K, Kaiser FJ
THAP1, the gene mutated in DYT6 dystonia, autoregulates its own expression
Biochim Biophys Acta. 2014 Aug 1. pii: S1874-9399(14)00207-7. doi: 10.1016/j.bbagrm.2014.07.019. [Epub ahead of print]
Huegel, S, Depping R, Dittmar G, Rother F, Cabot R, Sury MD, Hartmann E, Bader M
Identification of importin alpha 7 specific transport cargoes using a proteomic screening approach
Mol Cell Proteomics, [Epub ahead of print], 2014
van Rahden VA, Rau I, Fuchs S, Kosyna FK, de Almeida HL Jr, Fryssira H, Isidor B, Jauch A, Joubert M, Lachmeijer AM, Zweier C, Moog U, Kutsche K
Clinical spectrum of females with HCCS mutation: from no clinical signs to a neonatal lethal form of the microphthalmia with linear skin defects (MLS) syndrome
Orphanet J Rare Dis 9(1):53 [Epub ahead of print], 2014
Sun W, Depping R, Jelkmann W
Interleukin-1β promotes hypoxia-induced apoptosis of
glioblastoma cells by inhibiting hypoxia-inducible
factor-1 mediated adrenomedullin production
Cell Death and Disease 5, e1020; doi:10.1038/cddis.2013.562, 2014
Sun W, Jelkmann W, Depping R
Prolyl-4-hydroxylase 2 enhances hypoxia-induced glioblastoma cell death by regulating the gene expression of hypoxia-inducible factor-?
Cell Death Dis. 2014 Jul 10;5:e1322. doi: 10.1038/cddis.2014.295
Thunemann M, Schmidt K, de Wit C, Han X, Jain RK, Fukumura D, Feil R
Correlative intravital imaging of cGMP signals and vasodilation in mice
Front Physiol 5:394, 2014
2013
Erdmann J, Stark K, Esslinger UB, Rumpf PM, Koesling D, de Wit C, Kaiser
FJ, Braunholz D, Medack A, Fischer M, Zimmermann ME, Tennstedt S, Graf
E, Eck S, Aherrahrou Z, Nahrstaedt J, Willenborg C, Bruse P, Brænne I,
Nöthen MM, Hofmann P, Braund PS, Mergia E, Reinhard W, Burgdorf C,
Schreiber S, Balmforth AJ, Hall AS, Bertram L, Steinhagen-Thiessen E, Li
SC, März W, Reilly M, Kathiresan S, McPherson R, Walter U, Cardiogram,
Ott J, Samani NJ, Strom TM, Meitinger T, Hengstenberg C, Schunkert H
Dysfunctional nitric oxide signalling increases risk of myocardial
infarction
Nature 540:432-436, 2013
Gey C, Seeger K
Metabolic changes during cellular senescence investigated by proton NMR-spectroscopy
Mech Ageing Dev 134(3-4):130-8, 2013
Günter CI, Bader A, Dornseifer U, Egert S, Sebastian D, Grieb G, Wolter T, Pallua N, von Wild T, Siemers F, Mailänder P, Thamm O, Ernert C, Steen M, Sievers R, Reichert B, Rahmanian-Schwarz A, Schaller H, Hartmann B, Otte M, Kehl V, Ohmann C, Jelkmann W, Machens HG
A multi-center study on the regenerative effects of erythropoietin in burn and scalding injuries: study protocol for a controlled trial
Trials 14(1): 124, 2013
Mallavia B, Recio C, Oguiza A, Ortiz-Muñoz G, Lazaro I, Lopez-Parra V, Lopez-Franco O, Schindler S, Depping R, Egido J, Gomez-Guerrero C.
Peptide Inhibitor of Nuclear Factor-κB Translocation Ameliorates Experimental Atherosclerosis
Am J Pathol 182(5):1910-21, 2013
Radtke J, Schmidt K, Wulff H, Köhler R, de Wit C
Activation of KCa3.1 by SKA-31 induces arteriolar dilation and lowers blood pressure in normo- and hypertensive connexin40-deficient mice
Br J Pharmacol 170, 293-303,2013
Schmidt VJ, Hilgert JG, Covi JM, Weis C, de Wit C, Horch RE, Kneser U
High flow conditions increase connexin43 expression in a rat arteriovenous and angioinductive loop model
PLoS One 8:e78782, 2013
Thunemann M, Wen L, Hillenbrand M, Vachaviolos A, Feil S, Ott T, Han X,
Fukumura D, Jain RK, Russwurm M, de Wit C, Feil R
Transgenic mice for cGMP imaging
Circ Res 113: 365-371, 2013
Wolff M, Jelkmann W, Dunst J, Depping R
The aryl hydrocarbon receptor nuclear translocator (ARNT/HIF-1β) is influenced by hypoxia and hypoxia-mimetics.
Cell Physiol Biochem 32(4):849-858 [Epub ahead of print], 2013
2012
von Brandenstein M, Schlosser M, Richter C, Depping R, Fries JW
ETS-dependent p16(INK4a) and p21(waf1/cip1) gene expression upon endothelin-1 stimulation in malignant versus and non-malignant proximal tubule cells
Life Sci 91(13-14): 562-71, 2012
Damkjaer M, Nielsen G, Bodendiek S, Staehr M, Gramsbergen JB, de Wit C, Jensen BL, Simonsen U, Bie P, Wulff H, Köhler R
Pharmacological activation of KCa3.1/KCa2.3 channels produces endothelial hyperpolarisation and lowers blood pressure in conscious dogs
Br J Pharmacol 165(1): 223-34, 2012
Depping R, Schindler SG, Jacobi C, Kirschner KM, Scholz H
Nuclear Transport of Wilms' Tumour Protein Wt1 Involves Importins alpha and beta
Cell Physiol Biochem 29(1-2): 223-32, 2012
Flöter N, Schmidt T, Keck A, Reer R, Jelkmann W, Braumann KM
Bestimmung der individuellen anaeroben Schwelle mittels der Herzfrequenzvariabilität in Abhängigkeit von der sympathoadrenergen Aktivität
Dtsch Z Sportmed 63(2): 41-45, 2012
Jobs A, Schmidt K, Schmidt VJ, Lübkemeier I, van Veen TAB, Kurtz A, Willecke K, de Wit C
Defective Cx40 maintains Cx37 expression but intact Cx40 is crucial for conducted dilations irrespective of hypertension
Hypertension 60: 1422-1429, 2012
Knuever J, Poeggeler B, Gáspár E, Klinger M, Hellig-Buergel T, Hardenbicker C, Tóth Bl, Biró T, Paus R
Thyrotropin-Releasing Hormone Controls Mitochondrial Biology in Human Epidermis
J Clin Endocrinol Metab 97(3):978-86, 2012
Nolde J, de Wit C, Gemoll T, Schloericke E, Bruch HP, Laubert T
Regulation of tumor growth and angiogenesis in colorectal cancer
Eur Surg 44(5): 336-340, 2012
Pientka FK, Hu J, Schindler SG, Brix B, Thiel A, Joehren O, Fandrey J, Berchner-Pfannschmidt U, Depping R
Oxygen sensing by Prolyl-4-Hydroxylase PHD2 within the nuclear compartment and the influence of compartimentalisation on HIF-1 signalling
J Cell Sci 125(21): 5168-5176, 2012
Schmidt VJ, Jobs A, von Maltzahn J, Wörsdörfer P, Willecke K, de Wit C
Connexin45 is expressed in vascular smooth muscle but its function remains elusive
PLoS One 7: e42287, 2012
Wang L, Yin J, Nickles H, Ranke H, Tabuchi A, Hoffmann J, Tabeling C, Barbosa-Sicard E, Chanson M, Kwak BR, Shin HS, Wu S, Isakson B, Witzenrath M, de Wit C, Fleming I, Kuppe H, Kuebler WM
Hypoxic pulmonary vasoconstriction requires endothelial signal conduction via connexin40
J Clin Invest 122: 4218-4230, 2012
2011
Böttcher M, de Wit C
Distinct EDHFs emerge in vitro and in vivo and are mediated in part via
connexin40-dependent myoendothelial coupling
Hypertension 57: 802-808, 2011
von Brandenstein M, Depping R, Schäfer E, Dienes HP, Fries JW
Protein kinase C a regulates nuclear pri-microRNA 15a release as a part of endothelin signaling
Biochim Biophys Acta 1813(10): 1793-802, 2011
Brockmeier U, Platzek C, Schneider K, Patak P, Bernardini A, Fandrey J, Metzen E
The Function of Hypoxia-Inducible Factor (HIF) Is Independent of the Endoplasmic Reticulum Protein OS-9
Plos ONE, Volume 6: 4, 2011
Martrat G, et al.Exploring the link between MORF4L1 and risk of breast cancerBreast Cancer Res 13(2): R40, 2011
Ströfer M, Jelkmann W, Depping R
Curcumin Decreases Survival of Hep3B Liver and MCF-7 Breast Cancer Cells : The Role of HIF
Strahlenther Onkol 187(7): 393-400, 2011
Ströfer M, Jelkmann W, Metzen E, Brockmeier U, Dunst J, Depping R
Stabilisation and Knockdown of HIF - Two Distinct Ways Comparably Important in Radiotherapy
Cell Physiol Biochem 28:805-12, 2011
2010
Ao Z, Jayappa KD, Wang B, Zheng Y, Kung S, Rassart E, Depping R, Kohler M, Cohen EA,
Yao X
Importin {alpha}3 interacts with HIV-1 integrase and contributes to HIV-1 nuclear import and
replication
J Virol 84: 8650-63, 2010
Babin-Ebell J, Sievers HH, Charitos EI, Klein HM, Jung F, Hellberg AK, Depping R, Sier HA, Marxsen J
Stoelting S, Kraatz EG, Wagner KF
Transmyocardial Laser Revascularization Combined with Intramyocardial Endothelial Progenitor Cell Transplantation in Patients with Intractable Ischemic Heart Disease Ineligible for Conventional Revascularization: Preliminary Results in a Highly Selected Small Patient Cohort
Thorac Cardiov Surg 58: 11-16, 2010
Bodo E, Wiersma F, Funk W, Kromminga A, Jelkmann W, Paus R
Does erythropoietin modulate human hair follicle melanocyte activities in situ?
Exp Dermatol 19: 65-67, 2010
Böttcher M, Gloe T, de Wit C
Semiautomatic quantification of angiogenesis.
J Surg Res 162: 132-139, 2010
Chadjichristos CE, Scheckenbach KEL, van Veen TAB, Sarieddine MZR, de Wit C, Yang Z, Roth I, Bacchetta M, Viswambharan H, Foglia B, Dudez T, van Kempen MJA, Coenjaerts FEJ, Miquerol L, Deutsch U, Jongsma HJ, Chanson M, Kwak BR
Endothelial-specific deletion of Cx40 promotes atherosclerosis by increasing CD73-dependent leukocyte adhesion
Circulation 121: 123-131, 2010
de Wit C
Different pathways with distinct properties conduct dilations in the microcirculation in vivo.
Cardiovasc Res 85: 604-613, 2010
Huenniger K, Krämer A, Soom M, Chang I, Köhler M, Depping R, Kehlenbach RH, Kaether C.
Notch1 signaling is mediated by importins alpha 3, 4, and 7.
Cell Mol Life Sci 67: 3187-96, 2010
Milkau M, Köhler R, de Wit C
Crucial importance of the endothelial K+-channel SK3 and connexin40 in arteriolar dilations during skeletal muscle contraction
FASEB J 24: 3572-3579, 2010
Roth A, König P, van Zandbergen G, Klinger M, Hellwig-Bürgel T, Däubener W, Bohlmann MK, Rupp J
Hypoxia abrogates antichlamydial properties of IFN-{gamma} in human fallopian tube cells in vitro and ex vivo
PNAS 107: 19502-7, 2010
Schmidt K, Dubrovska G, Nielsen G, Fesüs G, Uhrenholt TR, Lærkegaard-Hansen P, Gudermann T, Dietrich A, Gollasch M,de Wit C, Köhler R
Amplification of EDHF-type vasodilatations in TRPC1-deficient mice
Br J Pharmacol 161: 1722-1733, 2010
Steichen-Gersdorf E, Griesmaier E, Pientka FK, Kotzot D, Kutsche K
A severe form of the X-linked microphthalia with linear skin defects syndrome in a female newborn
Clin Dysmorphol 19: 82-4, 2010
Wagner C, Jobs A, Schweda F, Kurtz L, Kurt B, Sequeira-Lopez M, Gomez R, van Veen TAB, de Wit C, Kurtz A
Selective deletion of connexin40 in renin-producing cells impairs renal baroreceptor function and is associated with arterial hypertension
Kidney Int 78: 762-8, 2010
2009
Ballal A, Saeed A, Rouina P, Jelkmann W
Effects of chloroquine treatment on circulating erythropoietin and inflammatory cytokines in acute Plasmodium falciparum malaria.
Ann Hematol 88: 411-5, 2009
Brähler S, Kaistha A, Schmidt VJ, Wölfle SE, Busch C, Kaistha BP, Kacik M, Hasenau AL, Grgic I, Si H, Bond CT, Adelman JP, Wulff H, de Wit C, Hoyer J, Köhler R
Genetic deficit of SK3 and IK1 channels disrupts the EDHF vasodilator pathway and causes hypertension.
Circulation 119: 2323-32, 2009
Groesdonk HV, Bauer A, Kreft B, Heringlake M, Paarmann H, Pagel H
Urodilatin and Pentoxifylline prevents the early onset of escherichia coli-induced acute renal failure in a model of isolated perfused rat kidney.
Kidney Blood Press Res 32: 81-90, 2009
Heinicke I, Böhler A, Rechsteiner T, Bogdanova A, Jelkmann W, Hofer M, Rawlings P, Araneda OF, Behn C, Gassmann M, Heinicke K
Moderate altitude but not additional endurance training increases markers of oxidative stress in exhaled breath condensate.
Eur J Appl Physiol 106: 599-604,2009
Just A, Kurtz L, de Wit C, Wagner C, Kurtz A, Arendshorst WJ
Connexin40 mediates tubuloglomerular feedback contribution to renal blood flow autoregulation
J Am Soc Nephrol 20: 1577-85, 2009
Schweda F, Kurtz L, de Wit C, Janssen-Bienhold U, Kurtz A, Wagner C
Substitution of connexin40 with connexin45 prevents hyperreninemia and attenuates hypertension.
Kidney Int 75: 482-9, 2009
Spanholtz T, Maichle A, Niedworok C, Stoeckelhuber BM, Krüger S, Wedel T, Aach T, Middeler G, Hellwig-Bürgel T, Bader A, Krengel S, Müller OJ, Franz WM, Lindenmaier W, Machens HG
Timing and targeting of cell-based VEGF165 gene expression in ischemic tissue.
J Surg Res 151: 153-62, 2009
Steinhoff A, Pientka FK, Möckel S, Kettelhake A, Hartmann E, Köhler M, Depping R
Cellular oxygen sensing: Importins and Exportins are mediators of intracellular localisation of Prolyl-4-Hydroxylases PHD1 and PHD2.
Biochem Biophys Res Commun 387: 705-11, 2009
Wölfle SE, Schmidt VJ, Hoyer J, Köhler R, de Wit C
Prominent role of KCa3.1 in EDHF-type dilations and conducted responses in the microcirculation in vivo.
Cardiovasc Res 82: 476-483, 2009
Wuelling M, Kaiser JF, Buelens LA, Braunholz D, Shivdasani RA, Depping R, Vortkamp A
Trps1, a regulator of chondrocyte proliferation and differentiation, interacts with the activator form of Gli3
Dev Biol 328: 40-53, 2009
2008
Aherrahrou Z, Doehring LC, Maria-Ehlers E, Liptau H, Depping R, Linsel-Nitschke P, Kaczmarek PM, Erdmann J, Schunkert H
An alternative splice variant in ABCC6, the gene causing dystrophic calcification, leads to protein deficiency in C3H/He mice.
J Biol Chem. 283: 7608-15, 2008
Asimakopoulos B, Abu-Hassan D, Metzen E, Al-Hasani S, Diedrich K, Nikolettos N
The levels of steroid hormones and cytokines in individual follicles are not associated with the fertilization outcome after intracytoplasmic sperm injection.
Fertil Steril 90: 60-4, 2008
Depping R, Steinhoff A, Schindler S, Friedrich B, Fagerlund R, Metzen E, Hartmann E, Köhler M
Nuclear translocation of hypoxia-inducible factors (HIFs): Involvement of the classical importin a/b pathway
Biochim Biophys Acta. 1783: 394-404, 2008
Hassouna I, Sperling S, Kim E, Schulz-Schaeffer W, Rave-Fränk M, Hasselblatt M, Jelkmann W, Giese A, Ehrenreich H
Erythropoietin augments survival of glioma cells after radiation and temozolomide.
Int J Radiat Oncol Biol Phys 72: 927-34, 2008
Laugsch M, Metzen E, Svensson T, Depping R, Jelkmann W
Lack of functional erythropoietin receptors of cancer cell lines.
Int J Cancer 122:1005-1011, 2008
Rantanen K, Pursiheimo J, Högel H, Himanen V, Metzen E, Jaakkola PM
Prolyl Hydroxylase PHD3 Activates Oxygen-dependent Protein Aggregation.
Mol Biol Cell 19: 2231-40, 2008
Schön MR, Hogrebe E, Hengstler JG, Donaubauer B, Faber SC, Bauer A, Pietsch UC, Jelkmann W, Thiery J, Hauss JP, Tannapfel A
Erythropoietin stimulates hepatocyte regeneration after liver resection.
Excli J 7: 79-92, 2008
von Brandenstein MG, Ngum Abety A, Depping R, Roth T, Koehler M, Dienes HP, Fries JW
A p38-p65 transcription complex induced by endothelin-1 mediates signal transduction in cancer cells.
Biochim Biophys Acta 1783: 1613-1622, 2008
Wagner AE, Huck G, Stiehl DP, Jelkmann W, Hellwig-Bürgel T
Dexamethasone impairs hypoxia-inducible factor-1 function.
Biochem Biophys Res Commun 372: 336-40, 2008
2007
Österborg A, Aapro M, Cornes P, Haselbeck A, Hayward CRW, Jelkmann W
Preclinical studies of erythropoietin receptor expression in tumor cells: Impact on clinical use of erythropoietic proteins to correct cancer-related anaemia.
Eur J Cancer 43: 510-519, 2007
Bodo E, Kromminga A, Funk W, Laugsch M, Duske U, Jelkmann W, Paus R Human hair follicles are an extrarenal source and a nonhematopoietic target of erythropoietin
The Faseb J 21: 3346-54, 2007
Bohm J, Kaiser FJ, Borozdin W, Depping R, Kohlhase J
Synergistic cooperation of Sall4 and Cyclin D1 in transcriptional repression. Biochem Biophys Res Commun 356: 773-9, 2007
Heidbreder M, Qadri F, Jöhren O, Dendorfer A, Depping R; Fröhlich R, Wagner KF, Dominiak P
Non-hypoxic induction of HIF-3α by 2-deoxy-D-glucose and insulin.
Biochem Biophys Res Commun 352: 437-43, 2007
Krajewski J, Batmunkh C, Jelkmann W, Hellwig-Bürgel T
Interleukin-1beta inhibits the hypoxic inducibillity of the erythropoietin enhancer by suppressing hepatocyte nuclear factor-4alpha.
Cell Mol Life Sci 64: 989-98, 2007
Kurtz L, Schweda F, de Wit C, Kriz W, Witzgall R, Warth R, Sauter A, Kurtz A, Wagner C
Lack of connexin40 causes displacement of renin-producing cells from afferent arterioles to the extraglomerular mesangium.
J Am Soc Nephrol 18: 1103-1111, 2007
Rodenwaldt B, Pohl U, de Wit C
Endogenous and exogenous NO attenuates the conduction of vasoconstrictions along arterioles in the microcirculation.
Am J Physiol Heart Circ Physiol 292:H2341-8 Epub 2007
Wagner C, de Wit C, Gerl M, Kurtz A, Höcherl K
Increased expression of cyclooxygenase 2 contributes to aberrant
renin production in connexin40 deficient kidneys
Am J Physiol Regul Integr Comp Physiol 293:R1781-R1786, 2007
Wagner C, de Wit C, Kurtz L, Grünberger C, Kurtz A, Schweda F
Connexin40 is essential for the pressure control of renin synthesis and secretion.
Circ Res 100: 556-563, 2007
Wotzlaw C, Otto T, Berchner-Pfannschmidt U, Metzen E, Acker H, Fandrey J
Optical analysis of the HIF-1 complex in living cells by FRET and FRAP.
FASEB J 21: 700-7, 2007
Wölfle SE, Schmidt VJ, Hoepfl B, Gebert A, Alcoléa S, Gros D, de Wit C
Connexin45 (Cx45) cannot replace the function of Cx40 in conducting
endothelium-dependent dilations along arterioles.
Circ Res 101: 1292-1299, 2007
2006
Asimakopoulos B, Nikolettos N, Nehls B, Diedrich K, Al-Hasani S, Metzen E.
Gonadotropin-releasing hormone antagonists do not influence the secretion of steroid hormones but affect the secretion of vascular endothelial growth factor from human granulosa luteinized cell cultures.
Fertil Steril 86: 636-41, 2006
Batmunkh C, Krajewski J, Jelkmann W, Hellwig-Burgel T
Erythropoietin production: Molecular mechanisms of the antagonistic actions of cyclic adenosine monophosphate and interleukin-1.
FEBS Lett 580: 3153-60, 2006
Hubold C, Oltmanns KM, Schultes B, Jelkmann W, Born J, Fehm HL, Schweiger U, Peters A
High plasma VEGF relates to low carbohydrate intake in patients with type 2 diabetesInt.
J Obes (Lond) 30: 1356-61, 2006
Griesinger G, Dafopoulos K, Schultze-Mosgau A, Jelkmann W, von Otte S, Diesing D, Diedrich K
Vascular endothelial growth factor response to exogenous chorionic gonadotropic hormone in the luteal phase of women with a history of severe ovarian hyperstimulation syndrome.
Arch Gynecol Obstet 274: 29-33, 2006
Si H, Heyken WT, Wölfle SE, Tysiac M, Schubert R, Grgic I, Vilianovich L, Giebing G, Maier T, Gross V, Bader M, de Wit C, Hoyer J, Köhler R
Impaired EDHF-mediated dilations and increased blood pressure in mice deficient of the intermediate-conductance Ca2+-activated K+-channel
Circ Res 99: 537-544, 2006
2005
Brinckmann J, Kim S, Wu J, Reinhardt DP, Batmunkh C, Metzen E, Notbohm H, Bank RA, Krieg T, Hunzelmann N
Interleukin 4 and prolonged hypoxia induce a higher gene expression of lysyl hydroxylase 2 and an altered cross-link pattern: important pathogenetic steps in early and late stage of systemic scleroderma?
Matrix Biol 24: 459-68, 2005
Burmester H, Wolber EM, Freitag P, Fandrey J, Jelkmann W
Thrombopoietin production in wild-type and interleukin-6 knockout mice with acute inflammation.
J Interfer Cytokine Res 25: 407-413, 2005
Callapina M, Zhou J, Schnitzer S, Metzen E, Lohr C, Deitmer JW, Brüne B
Nitric oxide reverses desferrioxamine- and hypoxia-evoked HIF-1alpha accumulation - implications for prolyl hydroxylase activity and iron.
Exp Cell Res 306:274-284, 2005
Dendorfer A, Heidbreder M, Hellwig-Bürgel T, Johren O, Qadri F, Dominiak P
Deferoxamine induces prolonged cardiac preconditioning via accumulation of oxygen radicals.
Free Radic Biol Med 38: 117-24, 2005
Depping R, Kawakami K, Ocker H, Wagner JM, Heringlake M, Noetzold A, Sievers HH, Wagner KF
Expression of the Erythropoietin Receptor in Human Heart.
J Thoracic and Carciovascular Surgery 130: 877-8, 2005
Depping R, Lohaus C, Meyer HE, Rüger W
The mono-ADP-ribosyltransferases Alt and ModB of bacteriophage T4: Target proteins identified.
Biochem Biophys Res Commun. 335: 1217-23, 2005
Doege K, Heine S, Jensen I, Jelkmann W, Metzen E
Inhibition of mitochondrial respiration elevates oxygen concentration, but leaves regulation of hypoxia-inducible factor (HIF) intact.
Blood 106: 2311-2317, 2005
Hellwig-Bürgel T, Stiehl D, Katschinski DM, Marxsen J, Kreft B, Jelkmann W
VEGF Production by Primary Human Renal Proximal Tubular Cells: Requirement of HIF-1, PI3-Kinase and MAPKK-1 Signaling.
Cell Physiol Biochem 15: 99-108, 2005
Hellwig-Bürgel T, Stiehl DP, Wagner AE, Metzen E, Jelkmann W
Hypoxia-inducible factor 1 (HIF-1): a novel transcription factor in immune reactions.
J Interfer Cytokine Res 25: 297-310, 2005
Martin F, Linden T, Katschinski DM, Oehme F, Flamme I, Mukhopadhyay CK, Eckhardt K, Troger J, Barth S, Camenisch G, Wenger RH
Copper-dependent activation of hypoxia-inducible factor (HIF)-1: implications for ceruloplasmin regulation.
Blood 105: 4613-4619, 2005
Metzen E, Stiehl DP, Doege K, Marxsen JH, Hellwig-Bürgel T, Jelkmann W
Regulation of the prolyl hydroxylase domain protein 2 (phd2/egln-1) gene: identification of a functional hypoxia-responsive element.
Biochem J 387: 711-7, 2005
Rupp J, Hellwig-Bürgel T, Wobbe V, Seitzer U, Brandt E, Maass M
Chlamydia pneumoniae infection promotes a proliferative phenotype in the vasculature through Egr-1 activation in vitro and in vivo.
Proc Natl Acad Sci USA 102: 3447-3452, 2005
Siegl D, Koeppen M, Wölfle SE, Pohl U, de Wit C
Myoendothelial coupling is not prominent in arterioles within the mouse cremaster microcirculation in vivo.
Circ Res 97: 781-788, 2005
Vaupel P, Dunst J, Engert A, Fandrey J, Feyer P, Freund M, Jelkmann W
Effects of recombinant human erythropoietin (rHuEPO) on tumor control in patients with cancer-induced anemia.
Onkologie 28: 216-21, 2005
von Wussow U, Klaus J, Pagel H
Is the renal production of erythropoietin controlled by the brain stem?
Am J Physiol Endocrinol Metab 289: E82-E86, 2005
Wölfle SE, de Wit C
Intact endothelium-dependent dilation and conducted responses in resistance vessels of hypercholesterolemic mice in vivo.
J Vasc Res 42: 475-482, 2005
2004
Berchner-Pfannschmidt U, Petrat F, Doege K, Trinidad B, Freitag P, Metzen E, de Groot H, Fandrey J
Chelation of Cellular Calcium Modulates Hypoxia-inducible Gene Expression through Activation of Hypoxia-inducible Factor-1 {alpha}.
J Biol Chem 279: 44976-44986, 2004
Depping R, Hagele S, Wagner KF, Wiesner RJ, Camenisch G, Wenger RH, Katschinski DM
A dominant-negative isoform of hypoxia-inducible factor-1alpha specifically expressed in human testis.
Biol Reprod 71: 331-9, 2004
Drenkhahn M, Gescher DM, Wolber EM, Meyhoefer-Malik A, Malik E
Expression of angiopoietin 1 and 2 in ectopic endometrium on the chicken chorioallantoic membrane.
Fertil Steril 81: 869-75, 2004
Hasegawa J, Wagner KF, Karp D, Li D, Shibata J, Heringlake M, Bahlmann L, Depping R, Fandrey J, Schmucker P, Uhlig S
Altered pulmonary vascular reactivity in mice with excessive erythrocytosis.
Am J Respir Crit Care Med 169: 829-35, 2004
Heringlake M, Heide C, Bahlmann L, Eichler W, Pagel H, Schmucker P, Wergeland R, Armbruster FP, Klaus S
Effects of tilting and volume loading on plasma levels and urinary excretion of relaxin, NT-pro-ANP, and NT-pro-BNP in male volunteers.
J Appl Physiol 97: 173-9, 2004
Katschinski D, Le L, Schindler S, Thomas T, Voss A, Wenger R
Interaction of he PAS B Domain with HSP90 Accelerates Hypoxia-Inducible Factor-1alpha Stabilization.
Cell Physiol Biochem 14: 351-60, 2004
Koeppen M, Feil R, Siegl D, Feil S, Hofmann F, Pohl U, de Wit C
cGMP-dependent protein kinase mediates NO- but not acetylcholine-induced dilations in resistance vessels in vivo.
Hypertension 44: 952-5, 2004
Marxsen JH, Stengel P, Doege K, Heikkinen P, Jokilehto T, Wagner T, Jelkmann W, Jaakkola P, Metzen E
Hypoxia-inducible factor-1 (HIF-1) promotes its degradation by induction of HIF-alpha-prolyl-4-hydroxylases.
Biochem J 381: 761-7, 2004
Perez de Lema G, Lucio-Cazana FJ, Molina A, Luckow B, Schmid H, de Wit C, Moreno-Manzano V, Banas B, Mampaso F, Schlöndorff D
Retinoic acid treatment protects MRL/lpr lupus mice from the development of glomerular disease.
Kidney Int 66: 1018-1028, 2004
Wagner KF, Hellberg AK, Balenger S, Depping R, Dodd-O J, Johns RA, Li D
Hypoxia-induced mitogenic factor has antiapoptotic action and is upregulated in the developing lung: coexpression with hypoxia-inducible factor-2alpha.
Am J Respir Cell Mol Biol 31: 276-82, 2004
2003
Dame C, Wolber EM, Freitag P, Hofmann D, Bartmann P, Fandrey J
Thrombopoietin gene expression in the developing human central nervous system.
Brain Res Dev Brain Res 143: 217-23, 2003
Gunga HC, Fries D, Humpeler E, Kirsch K, Boldt LE, Koralewski E, Johannes B, Klingler A, Mittermayr M, Rocker L, Yaban B, Behn C, Jelkmann W, Schobersberger W
Austrian Moderate Altitude Study (AMAS 2000) - fluid shifts, erythropoiesis, and angiogenesis in patients with metabolic syndrome at moderate altitude (congruent with 1700 m).
Eur J Appl Physiol 88: 497-505, 2003
Jabs WJ, Logering BA, Gerke P, Kreft B, Wolber EM, Klinger MH, Fricke L, Steinhoff J
The kidney as a second site of human C-reactive protein formation in vivo.
Eur J Immunol 33: 152-61, 2003
Katschinski DM, Marti HH, Wagner KF, Shibata J, Eckhardt K, Martin F, Depping R, Paasch U, Gassmann M, Ledermann B, Desbaillets I, Wenger RH
Targeted disruption of the mouse PAS domain serine/threonine kinase PASKIN.
Mol Cell Biol 23: 6780-6789, 2003
Klaus S, Heringlake M, Gliemroth J, Pagel H, Staubach K, Bahlmann L
Biochemical tissue monitoring during hypoxia and reoxygenation.
Resuscitation 56: 299-305, 2003
Linden T, Katschinski DM, Eckhardt K, Scheid A, Pagel H, Wenger RH
The antimycotic ciclopirox olamine induces HIF-1alpha stability, VEGF expression, and angiogenesis.
FASEB J 17: 761-3, 2003
Metzen E, Berchner-Pfannschmidt U, Stengel P, Marxsen JH, Stolze I, Klinger M, Huang WQ, Wotzlaw C, Hellwig-Bürgel T, Jelkmann W, Acker H, Fandrey J
Intracellular localisation of human HIF-1alpha hydroxylases: implications for oxygen sensing.
J Cell Sci 116: 1319-1326, 2003
Metzen E, Zhou J, Jelkmann W, Fandrey J, Brune B
Nitric Oxide Impairs Normoxic Degradation of HIF-1alpha by Inhibition of Prolyl Hydroxylases.
Mol Biol Cell 14: 3470-3481, 2003
2002
Dantz D, Bewersdorf J, Fruehwald-Schultes B, Kern W, Jelkmann W, Born J, Fehm HL, Peters A
Vascular endothelial growth factor: a novel endocrine defensive response to hypoglycemia.
J Clin Endocrinol Metab 87: 835-40, 2002
Hofer T, Wenger R H, Gassmann M
Oxygen sensing, HIF-1a stabilization and potential therapeutic strategies.
Eur J Physiol 443: 503-507, 2002
Hopfl G, Wenger RH, Ziegler U, Stallmach T, Gardelle O, Achermann R, Wergin M, Kaser-Hotz B, Saunders HM, Williams KJ, Stratford IJ, Gassmann M, Desbaillets I
Rescue of Hypoxia-inducible Factor-1alpha-deficient Tumor Growth by Wild-Type Cells Is Independent of Vascular Endothelial Growth Factor.
Cancer Res 62: 2962-70, 2002
La Ferla K, Reimann C, Jelkmann J, Hellwig-Bürgel T
Inhibition of erythropoietin gene expression signaling involves the transcription factors GATA-2 and NF-kappaB.
FASEB J 16: 1811-3, 2002
Schmitt O, Schubert C, Feyerabend T, Hellwig-Bürgel T, Weiss C, Kühnel W
Preferential Topography of Proteins Regulating Vascularization and Apoptosis in a MX1 Xenotransplant After Treatment With Hypoxia, Hyperthermia, Ifosfamide, and Irradiation.
Am J Clin Oncol 25: 325-36, 2002
Stiehl DP, Jelkmann W, Wenger RH, Hellwig-Bürgel T
Normoxic induction of the hypoxia-inducible factor 1a by insulin and interleukin-1ß involves the phosphatidylinositol 3-kinase pathway.
FEBS Lett 512: 157-162, 2002
Wolber EM, Haase B, Jelkmann W
Thrombopoietin Production in Human Hepatic Cell Cultures (HepG2) Is Resistant to IFN-alpha, IFN-ß, and IFN-gamma Treatment.
J Interfer Cytokine Res 22: 1185-1189, 2002
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